« Projects«

Hinamasens

Hybrid nanostructured materials for sensors with potential use in therapy and diagnosis.

2007-2009

Contract 71-004/18.09.2007

Coordinator

Institutul National de Cercetare Dezvoltare pentru Metale Neferoase si Rare IMNR Bucharest

Partners

Institutul National de Cercetare Dezvoltare pentru Microtehnologie IMT Bucharest
Institutul de Chimie Macromoleculara "Petru Poni" Bucharest
Institutul de Chimie ICHT Timisoara
Institutul de Biochimie BIOCHIM Bucharest
Sitex 45 Bucharest

Project

This project applies for the field of nanomedicine and it refers to regenerative medicine – tissue engineering. Tissue engineering deals with developing mimetic biological surfaces. This means elaboration of complex organic-inorganic hybrid structures with strong bonds between the two phases and high reactivity.
The aim of this project consists in: study and development of new hybrid materials based on hydroxyl apatite and organic macromolecular architectures with controlled structures at nanometer level, for sensors with potential applications in diagnosis (dependent on cell type – normal / malign in different stages – which could discriminate against normal cells and transformed cells, especially circulating ones) and therapy (e.g. monitoring restoration of bone tissue after surgical intervention dependent on cell number and ratification of their adhesion on bioactive layer); study and understanding of interactions between hybrid nanostructured material and cell; design and testing of functionality of nanostructured sensors for the measurement of adhesion and cell growth grade in tissue engineering.
Partners involved in the project proposal (3 R&D National Institutes, 3 Excellence Research Institutes of Romanian Academy and 2 SMEs) have great experience in the fields of:- nanostructured materials synthesis through non-conventional chemical routes; - microstructural characterization, electrical properties; - design and production of sensors and in vitro tests. One of the greatest challenges in the development of analytical means for biology is based on surface design with controlled interactions related to cells. Thus, three innovative directions are developed in the frame of proposed project: structuring of bioactive surface for guided cell growth, integrated studies of biomolecules behaviour at the interaction with nanostructured materials and achievement of sensing element. These directions involve very high risks and they are absolutely new at national level.

Results

The main results of this project are: fabrication of a device able to control conformation and activity of immobilized biomolecules, development of knowledge in the field of regenerative medicine which covers entirely in all-in-one unit material technology, sensing element and in vitro tests,as well as integration of the activities in the European Technological Platform NANOMEDICINE.

« Projects«